Predicting heart rejection response with spatial transcriptomics

Land acknowledgement

I would like to acknowledge that I work on the traditional, ancestral, and unceded territory of the Coast Salish Peoples, including the territories of the xwməθkwəy̓əm (Musqueam), Skwxwú7mesh (Squamish), Stó:lō and Səl̓ílwətaʔ/Selilwitulh (Tsleil- Waututh) Nations.

Traditional: Traditionally used and/or occupied by Musqueam people

Ancestral: Recognizes land that is handed down from generation to generation

Unceded: Refers to land that was not turned over to the Crown (government) by a treaty or other agreement

Background Heart Transplant

Background Heart Rejection

Background ACR vs Quilty

Background Types of data

Background In-house data

• Cite collaborators
• Or have their names and pic in here

Background what method to apply

• Need to know which method is most suitable to apply on this
• Which there really isnt any after the pipeline run

MESSI pipeline

• Overview pic of the pipeline

MESSI component cleaning

MESSI component evaluation

MESSI results on sim data

MESSI results on real data

MESSI future direction

Current work on GeoMX

Background of GeoMX

GeoMx results 1

GeoMx results 2

GeoMx results 3

GeoMx results 4

Next steps

Conclusion

Acknowledgments

Reference